Selective Down-regulation of KV2.1 Function Contributes to Enhanced Arterial Tone during Diabetes
نویسندگان
چکیده
منابع مشابه
Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.
Enhanced arterial tone is a leading cause of vascular complications during diabetes. Voltage-gated K(+) (KV) channels are key regulators of vascular smooth muscle cells (VSMCs) contractility and arterial tone. Whether impaired KV channel function contributes to enhance arterial tone during diabetes is unclear. Here, we demonstrate a reduction in KV-mediated currents (IKv) in VSMCs from a high f...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2015
ISSN: 0021-9258
DOI: 10.1074/jbc.m114.622811